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The ALPHA trial compares Alitretinoin and PUVA therapy in patients aged 18 years and over with severe hand eczema which is not controlled on a daily regular basis with prescription steroid creams. The purpose of the ALPHA research study is to find out the most effective treatment for chronic hand eczema. The two Worcester hot escort common treatments include 1 exposure of hands to ultra violet UV light after they have been soaked in a solution called psoralen a process referred to as PUVA and Alpa Leeds gay the tablet treatment Alitretinoin. Although both of these Alppa are equally used by doctors in standard clinical practice, there is no clear evidence indicating which of these two treatments is most effective in treating which type of hand eczema. This study will directly compare these two treatments to examine:. Close University links.

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